Modulation of sphingosine kinase signalling

C - Chemistry – Metallurgy – 12 – N

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C12N 9/00 (2006.01) A61K 48/00 (2006.01) A61P 29/00 (2006.01) C12N 9/99 (2006.01)

Patent

CA 2612644

The present invention relates generally to a method of modulating cellular activity and to agents for use therein. More particularly, the present invention provides a method of modulating the level of sphingosine kinase functional activity. In a related aspect, the present invention provides a method of modulating sphingosine kinase mediated signalling via modulation of its intracellular level of activity. The present invention still further extends to novel molecules which exhibit the capacity to induce sphingosine kinase activity. The methods and molecules of the present invention are useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate cellular functional activity and/or aberrant, unwanted or otherwise inappropriate sphingosine kinase mediated signalling. The present invention is further directed to methods for identifying and/or designing agents capable of modulating the level of sphingosine kinase activity.

Cette invention concerne, d~une manière générale, un procédé de modulation de l~activité cellulaire ainsi que les agents utilisés à cet effet. Cette invention concerne plus particulièrement un procédé de modulation du taux de l~activité fonctionnelle de la sphingosine kinase. Dans un mode de réalisation associé, cette invention prévoit un procédé de modulation de la signalisation induite par la sphingosine kinase via la modulation de son niveau d~activité intracellulaire. La présente invention se rapporte également à de nouvelles molécules qui offrent la capacité d~induire une activité sphingosine kinase. Les procédés et les molécules décrits dans cette invention sont utiles, entre autres, dans le traitement et/ou la prophylaxie de troubles se caractérisant par une activité fonctionnelle cellulaire anormale, indésirable ou inappropriée et/ou par une signalisation induite par la sphingosine kinase qui est anormale, indésirable ou inappropriée. Cette invention concerne également des procédés d~identification et/ou de conception d~agents capables de moduler le niveau d~activité sphingosine kinase.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Modulation of sphingosine kinase signalling does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modulation of sphingosine kinase signalling, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modulation of sphingosine kinase signalling will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1370823

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.