A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/44 (2006.01) A61K 35/14 (2006.01) A61K 35/28 (2006.01) C12N 5/00 (2006.01) C12N 5/02 (2006.01) A61K 35/12 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2481385
The present invention relates to methods of modulating mammalian stem cell and progenitor cell differentiation. The methods of the invention can be employed to regulate and control the differentiation and maturation of mammalian, particularly human stem cells along specific cell and tissue lineages. The methods of the invention relate to the use of certain small organic molecules to modulate the differentiation of stem or progenitor cell populations along specific cell and tissue lineages, and in particular, to the differentiation of embryonic-like stem cells originating from a postpartum placenta or for the differentiation of early progenitor cells to a granulocytic lineage. Finally, the invention relates to the use of such differentiated stem or progenitor cells in transplantation and other medical treatments.
L'invention concerne des procédés permettant de moduler la différenciation de cellule souche et de cellule progénitrice. Les procédés de l'invention peuvent être employés pour réguler et pour maîtriser la différenciation et la maturation de cellules souches de mammifères, en particulier d'êtres humains, le long de lignées cellulaires et tissulaires spécifiques. Les procédés de l'invention concernent l'utilisation de certaines molécules organiques de petite dimension destinés à moduler la différenciation de populations de cellules souches ou de cellules progénitrices le long de lignées cellulaires et tissulaires spécifiques, et en particulier, la différenciation de cellules souches de type embryonnaires provenant du placenta du post partum, ou la différenciation de cellules progénitrices précoces dans une lignée granulocytique. L'invention concerne en outre l'utilisation desdites cellules souches ou cellules progénitrices différenciées dans la transplantation et dans d'autres traitements médicaux.
Chan Kyle W. H.
Hariri Robert J.
Moutouh-De Parseval Laure A.
Stirling David I.
Celgene Corporation
Osler Hoskin & Harcourt Llp
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