C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/37 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2508690
Methods of directing stem cell fate for therapeutic purposes through the deliberate manipulation of caspase-3 activity are provided. The use of modulators of caspase-3 activity to modulate stem cell differentiation is described including activators and/or effectors of caspase-3, which can be used to induce stem cell differentiation, and inhibitors of caspase-3, which can be used to inhibit differentiation and thereby promote or maintain proliferation of stem cells. Methods of screening for modulators of caspase-3 and the use of such compounds to modulate stem cell differentiation in vitro or in vivo are also provided as are therapeutic applications of the compounds.
L'invention concerne des procédés permettant de diriger le destin de cellules souches à des fins thérapeutiques par manipulation délibérée de l'activité de la caspase-3. L'utilisation de modulateurs de l'activité de la caspase-3 afin de moduler la différenciation de cellules souches fait intervenir des activateurs et/ou des effecteurs de la caspase-3, qui peuvent être utilisés afin d'induire la différenciation de cellules souches, et des inhibiteurs de la caspase-3, qui peuvent être utilisés afin d'inhiber et ainsi de favoriser ou de maintenir la prolifération de cellules souches. L'invention concerne également des procédés de criblage de modulateurs de la caspase-3 et l'utilisation desdits composés afin de moduler la différenciation de cellules souches in vitroou in vivo, ainsi que des applications thérapeutiques desdits composés.
Fernando Pasan
Megeney Lynn
Borden Ladner Gervais Llp
Ottawa Health Research Institute
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