C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/113 (2010.01) A61K 31/713 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01)
Patent
CA 2756586
Compounds and compositions are provided for modulating the expression of survivin. The compounds, exemplified by those acting through an RNAi antisense mechanism of action, include double-stranded and single-stranded constructs, as well as siRNAs, canonical siRNAs, blunt-ended siRNAs and single-stranded antisense RNA compounds. Methods of using these compounds for modulation of survivin expression and for treatment of diseases associated with expression of survivin are provided.
Bhat Balkrishen
Patet Bharvin Kumar
Swayze Eric
Eli Lilly And Company
Gowling Lafleur Henderson Llp
Isis Pharmaceuticals Inc.
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