Modulation of survivin expression

Details Modulation of survivin expression Modulation of survivin expression

C - Chemistry, Metallurgy

07

H

C07H 21/02 (2006.01) C12N 15/113 (2010.01) A61K 31/713 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2524495

Compounds and compositions are provided for modulating the expression of survivin. The compounds, exemplified by those acting through an RNAi antisense mechanism of action, include double-stranded and single-stranded constructs, as well as siRNAs, canonical siRNAs, blunt-ended siRNAs and single-stranded antisense RNA compounds. Methods of using these compounds for modulation of survivin expression and for treatment of diseases associated with expression of survivin are provided.

L'invention concerne des composés et des compositions de modulation de l'expression de survivine. Les composés illustrés à titre d'exemple par ceux agissant par un mécanisme d'action antisens à ARNi comprennent des constructions bicaténaires et monocaténaires ainsi que des ARNsi, des ARNsi canoniques, des ARNsi à extrémité franche et des composés d'ARN antisens monocaténaires. L'invention concerne également des procédés d'utilisation de ces composés pour la modulation de l'expression de la survivine et dans le traitement de maladies associées à l'expression de survivine.

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