C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/715 (2006.01) A61P 37/02 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2389317
The present invention relates to methods for the treatment and diagnosis of immune related diseases, including those mediated by cytokines released primarily either Th1 or Th2 cells in response to antigenic stimulation. The present invention further relates to methods for biasing the differentiation of T-cells in either the Th1 subtype or the Th2 subtype, based on the relative expression levels of the gene TCCR, and its agonists or antagonists. The present invention further relates to a method of diagnosing Th1- and Th2- mediated diseases.
La présente invention concerne des procédés pour le traitement et le diagnostic de maladies d'ordre immunologique, comprenant notamment celles induites par des cytokines libérées principalement soit sous forme de cellules Th1, soit sous forme de cellules Th2, en réponse à une stimulation antigénique. La présente invention concerne également des procédés permettant d'orienter la différenciation de cellules T soit en sous-type Th1, soit en sous-type Th2, sur la base des niveaux d'expression relative du gène TCCR ou de ses agonistes ou antagonistes. La présente invention concerne également un procédé permettant de diagnostiquer des maladies induites par Th1 et Th2.
de Sauvage Frederic J.
Grewal Iqbal
Gurney Austin L.
Genentech Inc.
Smart & Biggar
LandOfFree
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