Modulation of t-cell receptor interactions

Details Modulation of t-cell receptor interactions Modulation of t-cell receptor interactions

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 35/14 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) G01N 33/50 (2006.01) G01N 33/543 (2006.01) G01N 33/547 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01) G01N 33/58 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2410642

Disclosed are methods for identifying compounds that modulate an immune complex that includes a T cell receptor (TCR) and a major histocompatibility complex (MHC) antigen. The invention has many useful applications including providing high throughput screening assays for detecting compositions that can modulate an immune response.

L'invention concerne des méthodes d'identification de composés qui modulent un complexe immun qui comprend un récepteur de cellules T (TCR) et un antigène de complexe d'histocompatibilité majeure (MHC). Les méthodes de cette invention s'avèrent utiles dans de nombreuses applications, y compris des dosages de criblage à rendement élevé destinés à la détection de compositions qui peuvent moduler une réponse immunitaire.

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