Modulation of t helper cell-mediated immune responses

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 37/02 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2684314

Provided herein are methods for modulating one or more of a T-helper cell or monocyte lineage cell-mediated immune response in a subject, the method comprises administering to the subject an effective amount of a compound which binds to surface membrane immunoglobulin D (smIgD). Also provided are methods of diagnosis of one or more of a T-helper cell or monocyte lineage cell-mediated immune disease, and compositions and kits for use in such methods.

L'invention concerne des procédés permettant de moduler une ou plusieurs réponses immunitaires induites par les lymphocytes T auxiliaires ou les cellules de la lignée des monocytes chez un malade, le procédé comprenant l'administration à un malade d'une quantité efficace d'un composé qui se lie à l'immunoglobine D de membrane de surface (smIgD). L'invention concerne également des procédés de diagnostic d'une ou plusieurs maladies immunitaires induites par les lymphocytes T auxiliaires ou les cellules de la lignée des monocytes et des compositions et des kits destinés à être utilisés dans de tels procédés.

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