C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/78 (2006.01) A61K 38/04 (2006.01)
Patent
CA 2739679
This invention relates to the finding that collagen peptides bind to the osteoclast-associated receptor (OSCAR) and stimulate the activation and/or differentiation of OSCAR expressing cells, such as osteoclasts and osteoclast precursor cells. Collagen peptides are described which may be useful in the modulation of the differentiation and/or activation of OSCAR expressing cells, for example in the treatment of bone defects and disorders characterized by altered differentiation and/or activation of OSCAR expressing cells.
La présente invention concerne la découverte que des peptides de collagène se lient au récepteur associé à l'ostéoclaste (OSCAR) et stimulent l'activation et/ou la différenciation des cellules d'expression d'OSCAR, telles que des ostéoclastes et des cellules précurseurs d'ostéoclastes. Les peptides de collagène décrits peuvent être utiles dans la modulation de la différenciation et/ou de l'activation de cellules d'expression d'OSCAR, par exemple dans le traitement de défauts et de troubles osseux caractérisés par la différenciation modifiée et/ou l'activation de cellules d'expression d'OSCAR.
Barrow Alexander
Farndale Richard
Trowsdale John
Cambridge Enterprise Limited
Dimock Stratton Llp
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