C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07K 1/22 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2401621
A method of modulating angiogenesis in a vertebrate subject, the method comprising administering to the vertebrate subject an ECRTP/DEP-1 activity- modulating amount of a composition, whereby an ECRTP/DEP-1 within the vertebrate subject is contacted by the composition ; and modulating angiogenesis through the contacting of the ECRTP/DEP-1 with the composition. Optionally, the composition includes a monoclonal antibody which preferentially binds ECRTP/DEP-1. Methods for screening for modulators of ECRTP/DEP-1 are also disclosed.
L'invention concerne un procédé de modulation de l'angiogenèse chez les vertébrés. Ce procédé consiste à administrer au sujet vertébré une composition à raison d'une dose apte à moduler l'activité de ECRTP/DEP-1, en faisant entrer un ECRTP/DEP-1 du sujet en contact avec cette composition, et à moduler l'angiogenèse par ce contact de ECRTP/DEP-1 avec la composition. La composition peut éventuellement comprendre un anticorps monoclonal qui se lie de manière préférentielle avec ECRTP/DEP-1. L'invention concerne en outre des procédés permettant d'identifier des modulateurs de ECRTP/DEP-1.
Daniel Thomas O.
Mernaugh Raymond
Takahashi Takamune
Norton Rose Or S.e.n.c.r.l.,s.r.l./llp
Vanderbilt University
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