A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) C12N 5/071 (2010.01) A61K 38/45 (2006.01) A61P 9/00 (2006.01) C12Q 1/02 (2006.01) C12N 9/12 (2006.01)
Patent
CA 2609937
Modulation of the mtegrin-linked kinase (ILK) signaling pathway is used to enhance the remodeling process relevant to a wide range of cardiac diseases More specifically, a process to instigate beneficial human cardiac hypertrophy or for post myocardial infarction (MI) remodeling comprising illiciting an overexpression of ILK, is described The ILK signaling pathway is also used as a means for cardiac stem cell proliferation and self-renewal
La modulation de la voie de signalisation de la kinase liée aux intégrines (ILK) est utilisée pour améliorer le processus de remodelage pertinent à une large gamme de maladies cardiaques. Cette invention concerne plus spécifiquement un procédé destiné à favoriser une hypertrophie cardiaque humaine bénéfique ou à produire un remodelage après infarctus du myocarde (MI), ce procédé consistant à déclencher une surexpression de l'ILK. La voie de signalisation de l'ILK sert également de moyen favorisant la prolifération et l'autorenouvellement des cellules souches cardiaques.
Coles John G.
Hannigan Gregory
Lu Huanzhang
Finlayson & Singlehurst
The Hospital For Sick Children
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