Modulation of the poliovirus receptor function

Details Modulation of the poliovirus receptor function Modulation of the poliovirus receptor function

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 31/00 (2006.01) A61K 31/7088 (2006.01) A61K 31/7105 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12Q 1/02 (2006.01) C12Q 1/04 (2006.01) G01N 33/574 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2516701

The present invention relates to the identification, the isolation and the use of molecules interfering with the function(s) mediated by the poliovirus receptor (PVR) on cells. The molecules can be used for the treatment of cells having a metastatic potential, metastasis and cancer. Further methods are provided that are useful for identifying and isolating molecules which have the capacity to modulate PVR mediated adhesion or invasion potential of cells.

La présente invention se rapporte à l'identification, à l'isolement et à l'utilisation de molécules faisant obstacle à la ou les fonctions causées par le récepteur du poliovirus (PVR) sur des cellules. Les molécules peuvent servir à traiter des cellules possédant un potentiel métastatique, la métastase et le cancer. L'invention concerne également des procédés utiles pour identifier et isoler des molécules qui peuvent moduler le potentiel d'adhésion ou d'invasion par PVR de cellules.

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