Modulation of thyroid hormone receptor interactor 3 expression

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 21/00 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2513354

Compounds, compositions and methods are provided for modulating the expression of thyroid hormone receptor interactor 3. The compositions comprise oligonucleotides, targeted to nucleic acid encoding thyroid hormone receptor interactor 3. Methods of using these compounds for modulation of thyroid hormone receptor interactor 3 expression and for diagnosis and treatment of disease associated with expression of thyroid hormone receptor interactor 3 are provided.

L'invention concerne des composés, des compositions et des méthodes permettant de moduler l'expression de la protéine d'interaction 3 du récepteur de l'hormone de la thyroïde. Ces compositions renferment des oligonucléotides ciblés sur un acide nucléique codant la protéine d'interaction 3 du récepteur de l'hormone de la thyroïde. Cette invention a aussi pour objet des méthodes d'utilisation de ces composés dans la modulation de l'expression de la protéine d'interaction 3 du récepteur de l'hormone de la thyroïde et dans le diagnostic et le traitement de maladie liée à l'expression de la protéine d'interaction 3 du récepteur de l'hormone de la thyroïde.

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