C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/113 (2010.01) A61K 31/7088 (2006.01) A61K 31/7125 (2006.01) A61K 45/06 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2733057
Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding TLR3. The compositions may also comprise antisense oligonucleotides targeted to nucleic acids encoding TLR3 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating TLR3 expression and for prevention or treatment of diseases wherein modulation of TLR3 expression would be beneficial are provided.
L'invention concerne des composés olignonucléotidiques antisens, des compositions et des procédés pour la régulation à la baisse de l'expression de TLR3. Les compositions comprennent des oligonucléotides antisens ciblés sur les acides nucléiques codant TLR3. Les compositions peuvent également comprendre des oligonucléotides antisens ciblés sur les acides nucléiques codant TRL3 en combinaison avec d'autres composés et/ou compositions thérapeutiques et/ou prophylactiques. L'invention concerne des procédés d'utilisation de ces composés et compositions pour la régulation à la baisse de l'expression de TLR3 et pour la prévention ou le traitement de maladies, pour lesquelles la modulation de l'expression de TLR3 serait bénéfique.
Agrawal Sudhir
Bhagat Lakshmi
Kandimalla Ekambar R.
Putta Mallikarjuna
Wang Daqing
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Idera Pharmaceuticals Inc.
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