C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/113 (2010.01) A61K 31/7088 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2742597
Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR4. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding TLR4. The compositions may also comprise antisense oligonucleotides targeted to nucleic acids encoding TLR4 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating TLR4 expression and for prevention or treatment of diseases wherein modulation of TLR4 expression would be beneficial are provided.
La présente invention concerne des composés oligonucléotides, des compositions et des procédés permettant de réguler à la baisse l'expression de TLR4. Lesdites compositions comprennent des oligonucléotides antisens dirigés vers des acides nucléiques codant pour TLR4. Ces compositions peuvent également comprendre des oligonucléotides antisens dirigés vers des acides nucléiques codant pour TLR4 en combinaison avec d'autres compositions et/ou composés thérapeutiques et/ou prophylactiques. La présente invention porte en outre sur des procédés d'utilisation de ces composés et de ces compositions pour la régulation à la baisse de l'expression de TLR4, et pour la prévention ou le traitement de maladies pour lesquelles la modulation de l'expression de TLR4 serait bénéfique.
Agrawal Sudhir
Bhagat Lakshmi
Kandimalla Ekambar
Putta Mallikarjuna
Wang Daqing
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Idera Pharmaceuticals Inc.
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