C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/113 (2010.01) A61K 31/7088 (2006.01) A61K 31/7125 (2006.01) A61P 37/06 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2732142
Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR9. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding TLR9. The compositions may also comprise anti sense oligonucleotides targeted to nucleic acids encoding TLR9 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating TLR9 expression and for prevention or treatment of diseases wherein modulation of TLR9 expression would be beneficial are provided.
Linvention concerne des composés oligonucléotides antisens, des compositions et des procédés permettant la régulation négative de lexpression de TLR9. Les compositions comprennent des oligonucléotides antisens dirigés contre les acides nucléiques codant TLR9. Les compositions peuvent également comprendre des oligonucléotides antisens dirigés contre les acides nucléiques codant TLR9 en combinaison avec dautres composés et/ou compositions thérapeutiques et/ou prophylactiques. Linvention porte sur des procédés dutilisation desdits composés et compositions permettant la régulation négative de lexpression de TLR9 et permettant le traitement ou la prévention de maladies pour lesquelles la modulation de lexpression de TLR9 savère bénéfique.
Agrawal Sudhir
Bhagat Lakshmi
Kandimalla Ekambar R.
Putta Mallikarjuna
Wang Daqing
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Idera Pharmaceuticals Inc.
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