Modulation of wrn-mediated telomere-initiated cell signaling

Details Modulation of wrn-mediated telomere-initiated cell signaling Modulation of wrn-mediated telomere-initiated cell signaling

C - Chemistry, Metallurgy

12

N

C12N 9/14 (2006.01)

Patent

CA 2566859

The use of modulators of WRN is described. Activators of WRN may be used to induce growth arrest, apoptosis or proliferative senescence, whereas inhibitors of WRN may be used to reduce growth arrest, apoptosis or prolifertative senescence. Methods of identifying modulators of WRN are also described.

L'invention concerne l'utilisation de modulateurs de WRN. On peut utiliser des activateurs de WRN pour induire l'interruption de croissance, l'apoptose ou la sénescence proliférative, tandis que l'on peut utiliser des inhibiteurs de WRN pour réduire l'interruption de croissance, l'apoptose ou la sénescence proliférative. L'invention concerne également des procédés permettant d'identifier des modulateurs de WRN.

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