Modulaton of alpha-6 integrin-mediated responses

Details Modulaton of alpha-6 integrin-mediated responses Modulaton of alpha-6 integrin-mediated responses

A - Human Necessities

61

K

A61K 38/04 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/17 (2006.01) A61K 38/39 (2006.01) C07K 5/00 (2006.01) C07K 5/08 (2006.01) C07K 5/083 (2006.01) C07K 5/103 (2006.01) C07K 14/435 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2409868

A method for modulating an alpha 6 subunit containing integrin-mediated signal transduction is described. The method involves contacting a cell with an effective integrin modulating amount of an alpha 6 subunit containing integrin- mediated signal transduction pathway modification agent. Preferred agents are peptides having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.

L'invention concerne un procédé de modulation d'une sous-unité alpha-6 contenant une transduction de signal induite par une intégrine. Ce procédé implique la mise en contact d'une cellule avec une quantité efficace d'intégrine de sous-unité alpha-6 contenant un agent de modification du mécanisme de transduction de signal induite par une intégrine. Les peptides correspondant à la formule f-Met-Leu-X, dans laquelle X est sélectionné dans le groupe constitué de Tyr, Tyr-Phe, Phe-Phe et Phe-Tyr, sont des agents préférés.

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