C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/12 (2006.01) C12N 15/113 (2010.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2680589
The use of compounds is described which are capable of functionally blocking at least one of the genes chosen from the group composed of EphA1, EphA2, EphA8, EphB2, CSF1R, VEGFR2, RAMP2, RAMP3, CLRN1, MAPK4, PIK3C2A, PIK3CG, GSK3alpha, GSK3beta, IRAK3, DAPK1, JAK1, PIM1, TRB3, BTG1, LATS1, LIMK2, MYLK, PAK1, PAK2, CDC2, BTK, PNRC2, NCOA4, NR2C1, TPR, RBBP8, TRPC7, FXYD1, ERN1, PRSS16, RPS3, CCL23 and SERPINE1, for the manufacture of a medicament destined to diminish the resistance to chemotherapeutic drugs in the therapeutic treatment of epithelial tumour pathologies. Also described is a method for the determination of the drug resistance in tumour cells, as well as a method forthe identification of tumour stem cells.
L'invention concerne l'utilisation de composés aptes à bloquer fonctionnellement au moins un des gènes choisis dans le groupe constitué par EphA1, EphA2, EphA8, EphB2, CSF1R, VEGFR2, RAMP2, RAMP3, CLRN1, MAPK4, PIK3C2A, PIK3CG, GSK3alpha, GSK3beta, IRAK3, DAPK1, JAK1, PIM1, TRB3, BTG1, LATS1, LIMK2, MYLK, PAK1, PAK2, CDC2, BTK, PNRC2, NCOA4, NR2C1, TPR, RBBP8, TRPC7, FXYD1, ERN1, PRSS16, RPS3, CCL23 et SERPINE1, dans la fabrication d'un médicament destiné à réduire la résistance à des produits chimiotérapeuthiques dans le traitement des pathologies tumorales épithéliales. L'invention concerne également une méthode permettant de détecter la pharmacorésistance dans des cellules tumorales, ainsi qu'une méthode d'identification de cellules souches tumorales.
Grassilli Emanuela
Helin Kristian
Lavitrano Marialuisa
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Universita Degli Studi Di Milano - Bicocca
LandOfFree
Modulator compounds of the drug resistance in epithelial... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modulator compounds of the drug resistance in epithelial..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modulator compounds of the drug resistance in epithelial... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1836543