Modulator of neuronal cell response to inhibition by cns myelin

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/55 (2006.01) C07K 14/47 (2006.01) C07K 16/22 (2006.01) C07K 16/28 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12N 9/16 (2006.01) C12Q 1/02 (2006.01) C12Q 1/42 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2217731

A method of assaying for a substance which modulates the response of neuronal cells to inhibition by adult central nervous system myelin. Neuronal cells which have a propensity for neurite growth are grown on mammalian central nervous system (CNS) myelin in the presence of a test substance which is suspected of affecting neurite outgrowth. The invention also relates to isolated nucleic acid molecules encoding a novel protein which plays a role in neurite outgrowth. The invention provides for various uses of the nucleic acid molecule and its protein product.

Procédé de détermination d'une substance modulant la réponse des cellules neuronales à l'inhibition par la myéline du système nerveux central d'un sujet adulte. On cultive des cellules neuronales présentant une propension à la croissance de neurites sur la myéline du système nerveux central (SNC) d'un mammifère, en présence d'une substance d'essai dont on soupçonne qu'elle a une influence sur l'excroissance des neurites. L'invention concerne également des molécules isolées d'acide nucléique codant une protéine nouvelle qui joue un rôle dans l'excroissance des neurites. L'invention décrit différentes utilisations de ladite molécule et de son produit protéinique.

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