C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/16 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 14/71 (2006.01) C07K 14/715 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/18 (2006.01) C12N 15/28 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2189983
The present invention generally concerns novel proteins which bind to the intracellular domains of the p55 and p75 TNF-Rs and the Fas-R, which are capable of modulating the function of the p55 and p75 TNF-Rs and the Fas-R, and the DNA sequences which encode them. The present invention also concerns new soluble oligomeric TNF-Rs, oligomeric Fas-Rs and oligomeric receptors having a mixture of TNF-Rs and Fas-Rs. In addition, the present invention concerns methods of preparation and uses of all of the aforementioned.
Nouvelles protéines qui se lient aux domaines intracellulaires des TNF-Rs (récepteurs de la famille du facteur de nécrose tumorale) p55 et p75 et de Fas-R, capables de moduler la fonction des TNF-Rs p55 et p75 et de Fas-R, et séquences d'ADN les codant. La présente invention concerne également de nouveaux TNF-Rs oligomères solubles, des Fas-R oligomères et des récepteurs oligomères présentant un mélange de TNF-Rs et de Fas-Rs. La présente invention concerne en outre des procédés de préparation et d'utilisation de toutes les substances susmentionnées.
Boldin Mark
Mett Igor
Varfolomeev Eugene
Wallach David
Gowling Lafleur Henderson Llp
Yeda Research And Development Co. Ltd.
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