Modulators for her2 signaling in her2 expressing patients...

A - Human Necessities – 61 – K

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A61K 39/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2761280

The present invention relates to means and methods for the identification of responders for or a patient sensitive to a modulator of the HER2/neu (ErbB2) signaling pathway. Also described herein are corresponding methods of treatment of a group of patients determined and defined in accordance with the identification method of the present invention, whereby said group of patients is known or suspected to suffer from or being prone to suffer from gastric cancer, in particular invasive gastric cancer.

La présente invention concerne des moyens et des procédés d'identification de répondeurs pour ou d'un patient sensible à un modulateur de la voie de signalisation HER2/neu (ErbB2). L'invention concerne également des procédés correspondants de traitement d'un groupe de patients déterminé et défini conformément au procédé d'identification de la présente invention, ledit groupe de patients étant reconnu souffrir ou étant susceptible de souffrir d'un cancer de l'estomac, en particulier, d'un cancer de l'estomac invasif.

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