Modulators of 5-ht receptors and methods of use thereof

Details Modulators of 5-ht receptors and methods of use thereof Modulators of 5-ht receptors and methods of use thereof

C - Chemistry, Metallurgy

07

D

C07D 498/04 (2006.01) C07D 471/04 (2006.01) C07D 471/14 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01) A61K 31/4985 (2006.01) A61K 31/551 (2006.01) A61K 31/553 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2759607

The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2- a][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7- octahydropyrazino[1,2-a][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1H-pyrido[3,4-d][2]benzazepine, 1,2,3,4,4a,5,6,7- octahydropyrazino[1,2-a][1]benzazepine, 1,2,3,4,4a,5- hexahydro-7H-pyrazino[1,2-a][4,1]benzoxazepine, and 2,3,4,4a,5,6-hex-ahydro-1H-pyrazino[2,1-d][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, X1, X2, X3, X4, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

La présente invention concerne la 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,4]benzodiazépine, la 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazépine, la 2,3,4,4a,5,6,7,11b-octahydro-1H-pyrido[3,4-d][2]benzazépine, la 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1]benzazépine, la 1,2,3,4,4a,5-hexahydro-7H-pyrazino[1,2-a][4,1]benzoxazépine, la 2,3,4,4a,5,6-hexahydro-1H-pyrazino[2,1-d][1,5]benzoxazépine, et des dérivés de 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazépine de formule (I), R1, R2, R3, R4, R5, R6, X1, X2, X3, X4, Y1, Y2, et Y3 étant définis dans la description. La présente invention concerne en outre des compositions comprenant de tels composés, des méthodes de traitement d'états pathologiques utilisant ces composés et ces compositions, et des méthodes d'identification de ces composés.

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