G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01)
Patent
CA 2722556
The invention relates to an in vitro method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, comprising the determination of the ability of a compound to modulate the expression or the activity of acetyl- coenzyme A acyltransferase 1(ACAA1) or of acetyl-coenzyme A acyltransferase 2 (ACAA2), and also to the use of modulators of the expression or of the activity of either of these enzymes, for the treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea. The invention also relates to methods for the in vitro diagnosis of or in vitro prognosis for these pathologies.
L'invention concerne un procédé in vitro de criblage de composés candidat pour la prévention ou le traitement curatif de l'acné, de la dermatite séborrhéique ou de troubles cutanés associés à l'hyperséborrhée, comprenant la détermination de la capacité d'un composé de moduler l'expression ou l'activité d'acétyl-coenzyme A acyltransférase 1 (ACAA1) ou d'acétyl-coenzyme A acyltransférase 2 (ACAA2), ainsi que l'utilisation de modulateurs de l'expression ou de l'activité de l'une ou de l'autre de ces enzymes, pour le traitement de l'acné, de la dermite séborrhéique ou de troubles cutanés associés à l'hyperséborrhée. L'invention concerne aussi des procédés de diagnostic in vitro ou de pronostic in vitro pour ces pathologies.
Aubert Jerome
Rivier Michel
Voegel Johannes
Galderma Research & Development
Robic
LandOfFree
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