Modulators of alpha-synuclein toxicity

Details Modulators of alpha-synuclein toxicity Modulators of alpha-synuclein toxicity

A - Human Necessities

61

K

A61K 38/00 (2006.01)

Patent

CA 2608198

Disclosed are genes that, when overexpressed in cells expressing alpha- synuclein, either suppress or enhance alpha-synuclein mediated cellular toxicity. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha- synuclein mediated toxicity.

L'invention concerne des gènes qui, lorsqu'ils sont surexprimés dans des cellules exprimant l'alpha-synucléine, soit éliminent soit augmentent la toxicité cellulaire induite par l'alpha-synucléine. Des composés modulant l'expression de ces gènes ou l'activité des protéines codées peuvent être utilisés pour inhiber la toxicité induite par l'alpha-synucléine et pour traiter ou prévenir des synucléinopathies, telles que la maladie de Parkinson. L'invention concerne en outre des méthodes d'identification d'inhibiteurs de la toxicité induite par l'alpha-synucléine.

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