C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 25/28 (2006.01) C12N 1/19 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) C12N 15/12 (2006.01) C12N 15/31 (2006.01)
Patent
CA 2589700
Disclosed are compositions and methods for modulating expression of genes that function at the step of ER of Golgi trafficking. Compounds that modulate expression of these genes of activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to threat of prevent synucleinopathies such as Parkinson~s disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.
L'invention porte sur des compositions et sur des procédés de modulation de l'expression de gènes qui agissent au niveau du réticulum endoplasmique (ER) sur le transport des vésicules golgiennes. Les composés qui modulent l'expression de ces gènes ou l'activité des protéines codées peuvent être utilisés pour inhiber la toxicité induite par l'alpha-synucléine et pour traiter ou prévenir les synucléinopathies telles que la maladie de Parkinson. L'invention porte également sur des procédés d'identification d'inhibiteurs de la toxicité induite par l'alpha-synucléine.
Cashikar Anil
Cooper Anthony A.
Gitler Aaron D.
Haynes Cole M.
Lindquist Susan L.
Gowling Lafleur Henderson Llp
The Curators Of The University Of Missouri
Whitehead Institute For Biomedical Research
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