Modulators of atp-binding cassette transporters

Details Modulators of atp-binding cassette transporters Modulators of atp-binding cassette transporters

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/404 (2006.01) A61P 3/00 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2742821

Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modula-tors of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

L'invention porte sur des composés et des compositions pharmaceutiquement acceptables de ceux-ci, lesquels sont utiles comme modulateurs de transporteurs à cassette de liaison à l'ATP (« ABC ») ou de fragments de ceux-ci, dont le régulateur de la conductance transmembranaire de la mucoviscidose (« CFTR »). La présente invention porte également sur des procédés de traitement de maladies à médiation par les transporteurs ABC utilisant les composés de la présente invention.

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