Modulators of atp-binding cassette transporters

Details Modulators of atp-binding cassette transporters Modulators of atp-binding cassette transporters

C - Chemistry, Metallurgy

07

D

C07D 317/68 (2006.01) A61K 31/36 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2635760

A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein: Each R1 is independently an optionally substituted C1-6 aliphatic, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted C3-10 membered cycloaliphatic or an optionally substituted 4 to 10 membered heterocycloaliphatic, carboxy, amido, amino, halo, or hydroxy, provided that at least one R1 is an optionally substituted aryl or an optionally substituted heteroaryl and said R1 is attached to the 3- or 4- position of the phenyl ring; R2 is hydrogen, an optionally substituted C1-6 aliphatic, an optionally substituted C3-6 cycloaliphatic, an optionally substituted phenyl, or an optionally substituted heteroaryl; Ring A is an optionally substituted cycloaliphatic or an optionally substituted heterocycloaliphatic where the atoms of ring A adjacent to C* are carbon atoms; Each R4 is an optionally substituted aryl or an optionally substituted heteroaryl; and n is 1, 2, 3, 4, or 5. Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

La présente invention concerne des composés et des compositions pharmaceutiquement acceptables, utilisés comme modulateurs des transporteurs à cassette liant l'ATP (ABC) ou leurs fragments, parmi lesquels le régulateur de la perméabilité transmembranaire de la fibrose kystique (CFTR). Cette invention traite aussi de procédés de traitement de maladies induites par le transporteur ABC utilisant les composés de la présente invention.

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