Modulators of atp-binding cassette transporters

Details Modulators of atp-binding cassette transporters Modulators of atp-binding cassette transporters

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/404 (2006.01) A61P 31/00 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2648719

Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

La présente invention concerne des composés et des compositions pharmaceutiquement acceptables desdits composés qui sont utilisables en tant que modulateurs des transporteurs de la cassette de liaison à l'ATP (ATP-Binding Cassette ; ABC) ou des fragments de ceux-ci, y compris le régulateur de la conductance membranaire impliqué dans la mucoviscidose (Cystic Fibrosis Transmembrane Conductance Regulator ; CFTR). L'invention concerne également des procédés de traitement des maladies induites par les transporteurs d'ABC en utilisant les composés de la présente invention.

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