Modulators of atp-binding cassette transporters

Details Modulators of atp-binding cassette transporters Modulators of atp-binding cassette transporters

C - Chemistry, Metallurgy

07

D

C07D 231/40 (2006.01) C07D 263/48 (2006.01) C07D 277/46 (2006.01) C07D 277/54 (2006.01) C07D 277/82 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 417/04 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 493/10 (2006.01)

Patent

CA 2554796

The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators (I) or a pharmaceutically acceptable salt thereof, wherein: Ht is a 5-membered heteroaromatic ring containing 1-4 heteroatoms selected from O, S, N or NH, wherein said ring is optionally fused to a 6-membered monocyclic or 10-membered bicyclic carbocyclic or heterocyclic, aromatic or non-aromatic ring, wherein Ht is optionally substituted with w occurrences of -WRw, wherein w is 0-5; ring A is 3-7 membered monocyclic ring having 0-3 heteroatoms selected from O, S, N, or NH, wherein ring A is optionally substituted with q occurrences of QRQ; ring B is optionally fused to 5-6 membered carbocyclic or heterocyclic, aromatic or non- aromatic ring .

Cette invention concerne des modulateurs de transporteurs de type cassette de liaison à l'ATP ("ABC") ou des fragments de ceux-ci, y compris le régulateur de la perméabilité transmembranaire de la fibrose kystique ("CFTR"), des compositions associées, ainsi que des procédés les utilisant. Cette invention concerne également des procédés de traitement de maladies induites par les transporteurs de type ABC faisant intervenir ces modulateurs.

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