C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/02 (2006.01) A61K 31/404 (2006.01) A61P 3/00 (2006.01) A61P 25/00 (2006.01) C07D 209/08 (2006.01) C07D 209/12 (2006.01) C07D 209/18 (2006.01)
Patent
CA 2742980
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
La présente invention concerne des composés et des compositions pharmaceutiquement acceptables de ceux-ci, utiles en tant que modulateurs des transporteurs de la cassette de liaison à lATP (« ABC ») ou des fragments de ceux-ci, comprenant le régulateur de conductance transmembranaire de la mucoviscidose (« CFTR »). La présente invention concerne également des procédés de traitement de maladies médiées par le transporteur ABC à laide des composés de la présente invention.
Bear Brian
Grootenhuis Peter D. J.
Hadida Ruah Sara S.
Mccartney Jason
Miller Mark T.
Gowling Lafleur Henderson Llp
Vertex Pharmaceuticals Incorporated
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