Modulators of atp-binding cassette transporters containing...

Details Modulators of atp-binding cassette transporters containing... Modulators of atp-binding cassette transporters containing...

C - Chemistry, Metallurgy

07

D

C07D 307/87 (2006.01) A61K 31/335 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) C07C 307/00 (2006.01) C07D 209/42 (2006.01) C07D 215/56 (2006.01) C07D 231/14 (2006.01) C07D 231/56 (2006.01) C07D 237/28 (2006.01) C07D 333/32 (2006.01)

Patent

CA 2540978

The present invention provides compounds of Formula (I) useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD, RE, A, and Z are described generally and in classes and subclasses below. The present invention also provides pharmaceutical compositions, methods and kits associated with Formula (I), useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.

L'invention porte sur des composés de formule (I), ou leurs sels pharmacocompatibles, modulateurs de l'activité des transporteurs ABC. Dans ladite formule: R<SP>B</SP>, n, B, R<SP>C</SP>, R<SP>D</SP>, R<SP>E</SP>, A, et Z sont décrit, répartis en classes et sous classes, dans la description. L'invention porte également sur des préparations pharmaceutiques, méthodes et trousses associés à la formule (I) utilisables comme modulateurs et pour le traitement de maladies et d'états pathologiques associés aux protéines transporteuses A, B et C.

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