C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) A61K 31/167 (2006.01) A61K 31/18 (2006.01) A61K 31/36 (2006.01) A61K 31/365 (2006.01) A61K 31/428 (2006.01) A61K 31/443 (2006.01) A61P 1/00 (2006.01) A61P 11/00 (2006.01) C07C 233/62 (2006.01) C07C 235/40 (2006.01) C07D 317/46 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2728985
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
La présente invention porte sur des composés et des compositions pharmaceutiquement tolérables comprenant lesdits composés, qui s'utilisent comme modulateurs de transporteurs de cassette de liaison à l'ATP (= ABC =) ou de fragments de ceux-ci, comprenant un régulateur de la conductance transmembranaire de la fibrose cystique (= CFTR =). La présente invention porte également sur des procédés de traitement de maladies induites par un transporteur ABC, au moyen de composés de la présente invention.
Bear Brian
Grootenhuis Peter
Hadida Ruah Sara
Mccartney Jason
Miller Mark
Smart & Biggar
Vertex Pharmaceuticals Incorporated
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