Modulators of bone homeostasis identified in a...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/10 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/51 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2457879

The invention relates to the field of molecular genetics and medicine. In particular, the present invention relates to the field of functional genomics, i.e., to a method for the identification of genes that function in regulating bone homeostasis, such as the induction of osteogenesis. In particular, the present invention relates to polynucleotides and the encoded polypeptides that are identified in a high-throughput screen designed to detect modulation of bone alkaline phosphatase activity. Moreover, the present invention relates to vectors, host cells, antibodies and diagnostic methods for detecting diseases involving the discovered polynucleotides, and therapeutic methods for treating such diseases. The invention further relates to methods and means for drug compound screens designed to develop new therapeutic strategies.

Cette invention relève du domaine de la génétique moléculaire et de la médecine, et plus particulièrement de la génomique fonctionnelle. Cette invention porte sur un procédé d'identification de gènes qui interviennent dans la régulation de l'homéostasie osseuse, telle que l'induction de l'ostéogenèse. Cette invention concerne en particulier des polynucléotides et les polypeptides codés qui sont identifiés lors d'un criblage à haut rendement visant à détecter la modulation de l'activité phosphatase alcaline osseuse. En outre, cette invention concerne des vecteurs, des cellules hôtes, des anticorps et des méthodes de diagnostic permettant de détecter des maladies faisant intervenir les polynucléotides découverts, ainsi que des méthodes thérapeutiques permettant de traiter de telles maladies. Cette invention porte également sur des méthodes et des agents de criblage de composés médicamenteux visant à développer de nouvelles stratégies thérapeutiques.

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