Modulators of cellular adhesion

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 409/12 (2006.01) A61K 31/4725 (2006.01) C07D 401/12 (2006.01) C07D 403/14 (2006.01) C07D 407/14 (2006.01) C07D 409/06 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2544678

The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).

La présente invention porte sur des composés de la formule (1) et des dérivés pharmaceutiquement acceptables de ces derniers, dans laquelle R¿1?-R¿4?, n, p, A, B, D, E, L et AR?1¿ sont tels que décrits généralement et sont dans des classes et des sous-classes mentionnées dans la description, et concerne en outre des compositions pharmaceutiques de ces composés, et des procédés d'utilisation de ces dernières dans le traitement de troubles médiés par la famille CD11/CD18 des molécules d'adhésion cellulaire (p.ex., LFA-1).

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