C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 31/12 (2006.01) A61K 31/415 (2006.01) A61K 31/4178 (2006.01) A61K 31/42 (2006.01) A61K 31/422 (2006.01) A61K 31/4704 (2006.01) A61K 31/505 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07D 261/18 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C07K 14/475 (2006.01) C12N 1/21 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2452445
The invention is directed to small organic molecules and peptides having the ability to mimic or agonize hepatocyte growth factor/ scatter factor (HGF/SF) activity, or inhibit or antagonize HGF/SF activity, the former useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction. Inhibition of cellular growth or proliferation is beneficial in the treatment, for example, of inflammatory diseases such as inflammatory joint and skin diseases, and dysproliferative diseases such as cancer.
L'invention concerne de petites molécules organiques et des peptides ayant la capacité de simuler ou d'antagoniser l'activité du facteur de croissance des hépatocytes/facteur de dispersion ou d'inhiber ou d'antagoniser l'activité précitée, cette dernière étant utilisée pour favoriser, par exemple, la vascularisation des tissus ou des organes afin de faciliter la cicatrisation des lésions ou des tissus ou d'augmenter ou rétablir le débit sanguin sur des tissus ischémiques tels que le coeur après un infarctus du myocarde. L'inhibition de la prolifération cellulaire est favorable au traitement, par exemple, des maladies inflammatoires telles que les maladies inflammatoires de la peau et des articulations, et des maladies dysprolifératives telles que le cancer.
Goldberg Itzhak D.
Pillarisetti Sivaram
North Shore-Long Island Jewish Health System
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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