Modulators of cftr

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 405/14 (2006.01) A61K 31/444 (2006.01) A61P 11/00 (2006.01) A61P 37/00 (2006.01) C07D 213/75 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2686838

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating CFTR mediated diseases using compounds of the present invention.

L'invention concerne des composés et leurs compositions pharmaceutiquement acceptables, qui sont utiles en tant que modulateurs des transporteurs de la cassette de liaison à l'ATP ("ABC"), ou des fragments de ceux-ci, y compris le régulateur de la conductance membranaire impliqué dans la mucoviscidose ("CFTR"). L'invention concerne également des procédés de traitement des maladies induites par les transporteurs de CFTR utilisant les composés de la présente invention.

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