Modulators of cystic fibrosis transmembrane conductance...

Details Modulators of cystic fibrosis transmembrane conductance... Modulators of cystic fibrosis transmembrane conductance...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61P 1/18 (2006.01) A61P 3/06 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2709301

The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof of formula (I), including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using such CFTR modulators.

L'invention concerne des modulateurs de transporteurs de cassette de liaison à l'ATP (= ABC =) ou de leurs fragments de formule (I), y compris le régulateur de conductance transmembranaire de fibrose cystique, leurs compositions et des procédés y étant associés. La présente invention concerne également des procédés de traitement de maladies utilisant de tels modulateurs de régulateur de conductance transmembranaire de fibrose cystique.

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