Modulators of cystic fibrosis transmembrane conductance...

Details Modulators of cystic fibrosis transmembrane conductance... Modulators of cystic fibrosis transmembrane conductance...

C - Chemistry, Metallurgy

07

D

C07D 487/08 (2006.01) A61K 31/4709 (2006.01) A61P 11/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2742042

The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR(Formula I) or pharmaceutically acceptable salts thereof, wherein: ring A is selected from: (a), (b), (c), (d), wherein: R1 is -CH3 -CF3 or -CN; R2 is hydrogen, -CH3, -CF3, -OH, or -CH2OH; R3 is hydrogen, - CH3, -OCH3, or -CN; provided that both R2 and R3 are not simultaneously hydrogen; and one of X and Y is nitrogen and the other is carbon.

La présente invention concerne des modulateurs du régulateur CFTR de la conductance transmembranaire de la mucoviscidose, des compositions desdits modulateurs, et des méthodes les utilisant. L'invention concerne également des méthodes de traitement de maladies à l'aide des modulateurs du CFTR (formule I) ou de leurs sels pharmaceutiquement acceptables, dans lesquels : le cycle A est choisi parmi : (a), (b), (c), (d), où : R1 représente -CH3, -CF3 ou -CN; R2 représente un hydrogène, -CH3, -CF3, -OH, ou -CH2OH; R3 représente un hydrogène, -CH3, -OCH3, ou -CN; sous réserve que R2 et R3 ne représentent pas tous les deux simultanément un hydrogène; et un des groupes X et Y représente un azote et l'autre un carbone.

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