A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/775 (2006.01) C07K 16/28 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2246561
The present invention broadly relates to the treatment, diagnosis, and prophylactic prevention of Alzheimer's disease. More specifically, the present invention relates to methods and compositions for preventing the endocytosis and cellular internalization of integral membrane amyloid .beta.-precursor protein (APP) and its subsequent catabolism by blocking or interfering with the association or binding of APP with members of the low density lipoprotein receptor family._________________________________________________
La présente invention se rapporte généralement au traitement, au diagnostic et la prophylaxie de la maladie d'Alzheimer. Plus particulièrement, l'invention se rapporte à des procédés et à des compositions pour la prévention de l'endocytose et de l'internalisation cellulaire de la protéine membranaire intégrale dite protéine précurseur .beta. amyloïde (APP) et de son catabolisme ultérieur en bloquant ou en interférant avec l'association ou la liaison de l'APP avec des membres de la famille de récepteurs de la lipoprotéine basse densité.
Hyman Bradley T.
Kounnas Maria Z.
Moir Robert D.
Strickland Dudley K.
Tanzi Rudolph E.
Mbm & Co.
The American National Red Cross
The General Hospital Corporation
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