A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 38/16 (2006.01) A61K 39/12 (2006.01) A61K 39/29 (2006.01) A61K 48/00 (2006.01) A61P 7/00 (2006.01) A61P 7/02 (2006.01) C07K 14/165 (2006.01) C07K 16/28 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2362566
The inventor has determined that the nucleocapsid protein from a hepatitis virus can induce the prothrombinase, fgl2. The inventor has further developed that LF-A1 also induces fgl-2. This allows for the development of therapeutic methods and compositions for modulating immune coagulation. In particular, inhibitors of the N-protein or gene or LF-A1 protein gene, or LF-A1 binding site on the fgl-2 promoter may be useful in inhibiting immune coagulation caused by a virus such as a hepatitis virus.
Dans cette invention, on a déterminé que la protéine capside nucléique provenant d'un virus hépatique pouvait induire la thromboplastine, fgl2. On a ensuite développé que LF-A1 induisait également fgl-2. Ces découvertes permettent de mettre au point des méthodes et des compositions thérapeutiques dans le but de moduler la coagulation immune. Plus particulièrement, on peut utiliser les inhibiteurs du gène ou de la protéine N ou du gène protéique LF-A1, ou du site de liaison LF-A1 sur le promoteur thefgl-2 pour inhiber la coagulation immune provoquée par un virus tel qu'un virus hépatique.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Levy Gary
LandOfFree
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