C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/32 (2006.01) C12N 9/04 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2656841
The invention relates to an in vitro method of screening for candidate compounds for the preventive or curative treatment of acne, comprising the determination of the ability of a compound to modulate expression or the activity of 17-beta-hydroxysteroid dehydrogenase 7, and also to the use of modulators of the expression or of the activity of this enzyme for the treatment of acne or of skin disorders associated with hyperseborrhoea. The invention also relates to methods for the in vitro diagnosis or in vitro prognosis of these pathologies.
L'invention concerne une méthode in vitro de criblage de composés candidats pour le traitement préventif ou curatif de l'acné, comprenant la détermination de la capacité d'un composé à moduler l'expression ou l'activité de l'hydroxystéroïde (17-beta) deshydrogénase de type 7, ainsi que l'utilisation de modulateurs de l'expression ou de l'activité de cette enzyme pour le traitement de l'acné ou des désordres cutanés associés à une hyperséborrhée. L'invention concerne aussi des méthodes de diagnostic in vitro ou pronostic in vitro de ces pathologies.
Aubert Jerome
Calvo Ezequiel L.
Deret Sophie
Labrie Fernand
Luu-The Van
Galderma Research & Development
Robic
LandOfFree
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