G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2722595
The invention relates to an in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, comprising the determi-nation of the ability of a compound to modulate the expression or the activity of isovaleryl-coenzyme A dehydrogenase (IVD), and also to the use of modulators of the expression or of the activity of this enzyme, for the treatment of acne, of seborrhoeic der-matitis or of skin disorders associated with hyperseborrhoea. The invention also relates to methods for the in vitro diagnosis of or in vitro prognosis for these pathologies.
L'invention concerne une méthode in vitro ou in vivo pour cribler des composés candidats à utiliser dans le traitement préventif ou curatif de l'acné, de la dermatite séborrhéique ou de maladies de la peau associées à l'hyperséborrhée. La méthode de l'invention consiste à déterminer la capacité d'un composé à moduler l'expression ou l'activité de l'isovaléryl-coenzyme A déshydrogénase (IVD), et à utiliser des modulateurs de l'expression ou de l'activité de cette enzyme, pour le traitement de l'acné, de la dermatite séborrhéique ou de maladies de la peau associées à l'hyperséborrhée. L'invention concerne également des méthodes pour le diagnostic in vitro ou le pronostic in vitro de ces pathologies.
Aubert Jerome
Minier Tony
Rivier Michel
Trinquet Valerie
Galderma Research & Development
Robic
LandOfFree
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