Modulators of lxr

Details Modulators of lxr Modulators of lxr

C - Chemistry, Metallurgy

07

D

C07D 213/64 (2006.01) A61K 31/4412 (2006.01) A61K 31/4418 (2006.01) C07D 213/85 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/04 (2006.01) C07D 413/06 (2006.01) C07D 417/04 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2469435

Coumpounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of nuclear receptors, including liver X receptor (LXR) and orphan nuclear receptors. In certain embodiments, the compounds are N- substituted pyridones.

Composés, compositions et méthodes de modulation de l'activité de récepteurs nucléaires. L'invention concerne en particulier des composés hétérocycliques modulant l'activité de récepteurs nucléaires, dont le récepteur X du foie (LXR) et des récepteurs nucléaires orphelins. Dans certains modes de réalisation, les composés sont représentés par des pyrodones substitués N.

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