Modulators of melanocortin receptor

Details Modulators of melanocortin receptor Modulators of melanocortin receptor

C - Chemistry, Metallurgy

07

D

C07D 295/12 (2006.01) A61K 31/44 (2006.01) A61P 3/00 (2006.01) C07C 279/22 (2006.01) C07D 207/12 (2006.01) C07D 207/14 (2006.01) C07D 207/16 (2006.01) C07D 207/22 (2006.01) C07D 209/14 (2006.01) C07D 211/26 (2006.01) C07D 211/34 (2006.01) C07D 211/60 (2006.01) C07D 211/62 (2006.01) C07D 213/40 (2006.01) C07D 217/02 (2006.01) C07D 233/88 (2006.01) C07D 239/16 (2006.01) C07D 239/42 (2006.01) C07D 295/13 (2006.01) C07D 295/18 (2006.01) C07D 295/185 (2006.01) C07D 307/79 (2006.01) C07D 333/20 (2006.01) C07D 333

Patent

CA 2508914

This invention provides compounds and methods for treating melanocortin receptor associated disorders, such as weight loss disorders including cachexia resulting from cancer and other chronic illnesses. The compounds are represented by formula I: wherein X is oxygen or sulfur; G is G1 or G2: L1, L2, L3 and Q are linker groups, and Rings A, B and C, and R1-R14 are described in the specification. The compounds are antagonists of melanocortin receptors.

L'invention concerne des composés et des procédés pour traiter des troubles associés au récepteur de la mélanocortine, tels que des troubles de perte de poids, notamment l'émaciation résultant d'un cancer et d'autres maladies chroniques. Lesdits composés sont représentés par la formule (I), dans laquelle X représente oxygène ou soufre ; G représente les formules G1 ou G2, dans lesquelles L¿1?, L¿2?, L¿3? et Q sont des groupes lieurs, et les noyaux A, B et C et R?1¿-R?14¿ sont spécifiés dans la description. Lesdits composés sont des antagonistes des récepteurs de la mélanocortine.

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