Modulators of metabolism and the treatment of disorders...

Details Modulators of metabolism and the treatment of disorders... Modulators of metabolism and the treatment of disorders...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/506 (2006.01) A61P 3/00 (2006.01)

Patent

CA 2656623

The present invention relates to 4-[5-Methoxy-6-(2-methyl-6-[l,2,4]triazol-l-yl-pyridin-3- ylamino)-pyrimidin-4-yloxy]-piperidine-l -carboxylic acid isopropyl ester, pharmaceutically acceptable salts, solvates and hydrates thereof that are modulators of glucose metabolism. Accordingly, compounds of the present invention are useful in the treatment of metabolic-related disorders and complications thereof, such as, diabetes and obesity. (Formula I)

L'invention concerne un ester isopropylique de l'acide 4-[5-méthoxy-6-(2-méthyl-6-[1,2,4]triazol-1-yl-pyridin-3-ylamino)-pyrimidin-4-yloxy]-pipéridine-1-carboxylique, ainsi que des sels pharmaceutiquement acceptables, des solvates et des hydrates de ce composé. Ces substances sont des modulateurs du métabolisme du glucose et peuvent par conséquent servir à traiter des troubles métaboliques et des complications de ces troubles, telles que le diabète et l'obésité.

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