C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2448567
The biological activity of nucleic acid ligand is regulated (i.e. enhanced or inhibited) in vivo to produce a desired biological effect. This is accomplished through the administration of a modulator, or regulator, that changes the binding of the nucleic acid ligand for its target or that degrades or otherwise cleaves, metabolizes or breaks down the nucleic acid ligand while the ligand is still exerting its effect. Modulators of the present invention can be administered in real time as needed based on various factors, including the progress of the patient, as well as the physician's discretion in how to achieve optimal therapy. Thus, this invention provides for the first time a regulatable therapeutic regime in the course of nucleic acid ligand therapy.
Selon l'invention, l'activité biologique du ligands d'acides nucléiques est régulée (c'est-à-dire, renforcée ou inhibée) in vivo afin de produire un effet biologique souhaité. A cet effet, on administre un modulateur ou un régulateur qui change la liaison du ligand d'acides nucléiques pour sa cible ou qui dégrade, clive, métabolise ou décompose le ligand d'acides nucléiques pendant que ligand continue d'exercer son effet. Les modulateurs selon l'invention peuvent être administrés en temps réel selon le cas, en fonction de différents facteurs, notamment l'évolution du patient ou l'appréciation du médecin pour ce qui est des moyens d'appliquer un traitement optimal. Par conséquent, l'invention fournit, pour la première fois, un régime thérapeutique régulable au cours d'un traitement au ligand d'acide nucléiques.
Rusconi Christopher
Sullenger Bruce A.
Duke University
Mbm Intellectual Property Law Llp
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