Modulators of ob gene and screening methods therefor

Details Modulators of ob gene and screening methods therefor Modulators of ob gene and screening methods therefor

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 31/20 (2006.01) A61K 31/23 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/57 (2006.01) A61K 35/60 (2006.01) A61K 38/28 (2006.01) C07K 14/575 (2006.01) C12N 15/67 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2215387

This invention relates to the isolation and cloning of the promoter and other control regions of a human ob gene. It provides a method for identifying and screening for agents useful for the treatment of diseases and pathological conditions affected by the level of expression of an ob gene. These agents interact directly or indirectly with the promoter or other control regions of the ob gene. A PPAR.gamma. agonist, BRL49653, has been identified to be useful in treating anorexia, cachexia, and other diseases characterized by insufficient food intake or body weight loss. Modulators of ob gene expression may be used to treat other diseases such as obesity, diabetes, hypertension, cardiovascular diseases and infertility.

La présente invention porte sur l'isolement et le clonage du promoteur et d'autres régions de régulation d'un gène ob humain. L'invention renferme une méthode permettant de reconnaître et de cribler les agents utiles dans le traitement de maladies et d'états pathologiques qui dépendent du niveau d'expression d'un gène ob. Ces agents interagissent directement ou indirectement avec le promoteur ou d'autres régions de régulation du gène ob. Il a été reconnu qu'un agoniste gamma du PPAR, le BRL49653, est utile dans le traitement de l'anorexie, de la cachexie et d'autres maladies caractérisées par une sous-alimentation ou une perte de poids. Des modulateurs de l'expression du gène ob peuvent servir à traiter d'autres maladies comme l'obésité, le diabète, l'hypertension, les maladies cardiovasculaires et l'infécondité.

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