Modulators of p-selectin glycoprotein ligand 1

Details Modulators of p-selectin glycoprotein ligand 1 Modulators of p-selectin glycoprotein ligand 1

A - Human Necessities

61

K

A61K 38/17 (2006.01)

Patent

CA 2538284

Multimeric compounds that bind to P-Selectin Glycoprotein 1 (PSGL-1) on the surface of T cells or natural killer (NK) cells can be used to induce T cell or NK cell depletion and/or to induce T cell or NK cell apoptosis. The multimeric compounds and methods of the invention can be used to control unwanted T cell-or NK cell-mediated immune responses in conditions such as inflammatory diseases, autoimmune diseases, transplant rejection, and allergic diseases.

Les composés multimères qui se lient à la glycoprotéine 1 p-sélectine (PSGL-1) sur la surface de lymphocytes T ou des cellules NK peuvent s'utiliser pour induire la déplétion et/ou l'apoptose desdites cellules. On peut utiliser ces composés multimères et les méthodes de l'invention pour réduire une réponse immunitaire indésirable induite par des lymphocytes T ou des cellules NK dans le cas notamment de maladies inflammatoires, de maladies auto-immunes, de rejets de transplantations ou d'affections allergiques.

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