Modulators of polysaccharides and uses thereof

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/00 (2006.01) A61K 38/03 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01)

Patent

CA 2366604

The present invention provides peptides with a specific affinity for glycosaminoglycan molecules. These peptides may have any number of functions, including but not limited to use as inhibitors of glycosaminoglycan-mediated processes, enhancers of glycosaminoglycan-mediated processes, and as molecular probes to identify the presence of a specific glycosaminoglycan. Peptides of the invention may be directed against any glycosaminoglycan, including hyaluronic acid, chondroitin sulfate A, chondroitin sulfate C, dermatan sulfate, heparin, keratan sulfate, keratosulfate, chitin, chitosan 1, and chitosan 2. These isolated peptides may have therapeutic uses in the treatment or prevention of diseases involving infection, inflammatory diseases, cancer, infections, etc. The peptides may also have other biological functions such as contraception.

L'invention concerne des peptides ayant une affinité pour les molécules de glycosaminoglycane. Ces peptides peuvent avoir n'importe quel nombre de fonctions, et peuvent être utilisés, entre autres, en tant qu'inhibiteurs de processus médiés par le glycosaminoglycane, en tant qu'activateurs de processus médiés par glycosaminoglycane, et en tant que sondes moléculaires pour l'identification de la présence d'un glycosaminoglycane spécifique. Les peptides de l'invention peuvent être dirigés contre tout aminoglycane, quel qu'il soit, dont l'acide hyaluronique, le sulfate de chondroïtine A, le sulfate de chondroïtine C, le dermatan sulfate, l'héparine, le kératan sulfate, le kératosulfate, la chitine, le chitosan 1 et le chitosan 2. Ces peptides isolés peuvent être utilisés à des fins thérapeutiques dans le traitement ou la prévention de maladies impliquant l'infection, de maladies inflammatoires, du cancer, d'infections, etc. Lesdits peptides peuvent avoir d'autres fonctions biologiques, telles que la contraception.

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